Achillea goniocephala Extract Loaded into Nanochitosan: In Vitro Cytotoxic and Antioxidant Activity

The present study aimed to prepare A. goniocephala chloroform extract and evaluate antioxidant cytotoxic effects. Then, the nanoparticles (NPs) were synthesized on most efficient extracts biological activities of free forms compared with NPs forms. Antioxidant capacities 14 by column chromatography found FRAP, DPPH CUPRAC methods. Again, all fractions evaluated MCF-7 HT-29 cell lines using XTT viability assay. Chitosan-tripolyphosphate (TPP) formed ionic gelation method H F extracts, which show active properties because activities. characterized also evaluated. particle size from two obtained between 274.12 296.25 nm. extract-encapsulation loading-efficiency 77.6± 0.04% 7.76± 0.01% for 10.2± 0.02% 1.39± 0.07% extract, respectively. Anticancer activity chitosan gave better results unencapsulated extracts. As a result, it was that can be encapsulated in has an more anticancer effect than